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Titolo:
Adrenal and sex steroid receptor evolution: environmental implications
Autore:
Baker, ME;
Indirizzi:
Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 pt Med, La Jolla, CA 92093 USA
Titolo Testata:
JOURNAL OF MOLECULAR ENDOCRINOLOGY
fascicolo: 2, volume: 26, anno: 2001,
pagine: 119 - 125
SICI:
0952-5041(200104)26:2<119:AASSRE>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORPHAN NUCLEAR RECEPTORS; EEL ANGUILLA-JAPONICA; ANDROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; BINDING DOMAIN; LIGAND-BINDING; RAINBOW-TROUT; CDNA CLONING; ESTROGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Baker, ME Univ Calif San Diego, Dept Med, 0823,9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 0823,9500 Gilman Dr La Jolla CA USA 92093 A
Citazione:
M.E. Baker, "Adrenal and sex steroid receptor evolution: environmental implications", J MOL ENDOC, 26(2), 2001, pp. 119-125

Abstract

The nuclear receptor family responds to a diverse group of ligands, including steroids, retinoids, thyroid hormone, prostaglandins and fatty acids. Previous sequence analyses of adrenal and sex steroid receptors indicate that they form a clade separate from other nuclear receptors. However, the relationships of adrenal and sex steroid receptors to each other and to their ancestors are not fully understood. We have used new information from androgen, estrogen, mineralocorticoid and progesterone receptors in fish to better resolve the phylogeny of adrenal and sex steroid receptors. Sequence divergence between fish and mammalian steroid receptors correlates with differences in steroid specificity, suggesting that phylogeny needs to be considered in evaluating the endocrine effects of xenobiotics. Among the vertebrate steroid receptors, the most ancient is the estrogen receptor. The phylogeny indicates that adrenal and sex steroid receptors arose in a jawless fishor a protochordate and that changes in the sequence of the hormone-bindingdomain have slowed considerably in land vertebrates. The retinoid X receptor clade is closest to the adrenal and sex steroid receptor clade. RetinoidX receptor is noteworthy for its ability to form dimers with other nuclearreceptors,' an important mechanism for regulating the action of retinoid Xreceptor and its dimerization partners. In contrast, the adrenal and sex steroid receptors bind to DNA as homodimers. Moreover, unliganded adrenal and sex steroid receptors form complexes with heat shock protein 90. Thus, the evolution of adrenal and sex steroid receptors involved changes in protein-protein interactions as well as ligand recognition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/05/18 alle ore 13:00:04