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Titolo:
Roles of an endogenous serum lectin in the immune protection of blue gourami, Trichogaster trichopterus (Pallus) against Aeromonas hydrophila
Autore:
Fock, WL; Chen, CL; Lam, TJ; Sin, YM;
Indirizzi:
Natl Univ Singapore, Dept Biol Sci, Singapore 119260, Singapore Natl Univ Singapore Singapore Singapore 119260 ngapore 119260, Singapore
Titolo Testata:
FISH & SHELLFISH IMMUNOLOGY
fascicolo: 2, volume: 11, anno: 2001,
pagine: 101 - 113
SICI:
1050-4648(200102)11:2<101:ROAESL>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANNOSE-BINDING LECTIN; ANIMAL LECTINS; RAINBOW-TROUT; SYSTEM; MACROPHAGES; FISH; SALMONICIDA; COLLECTINS; RESISTANCE; PHAGOCYTES;
Keywords:
blue gourami Trichogaster trichopterus; fish serum lectin; laminarin; Aeromonas hydrophila; phagocytic activity; killing activity; non-specific immune response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Sin, YM Natl Univ Singapore, Dept Biol Sci, 10 Kent Ridge Crescent, Singapore 119260, Singapore Natl Univ Singapore 10 Kent Ridge Crescent SingaporeSingapore 119260
Citazione:
W.L. Fock et al., "Roles of an endogenous serum lectin in the immune protection of blue gourami, Trichogaster trichopterus (Pallus) against Aeromonas hydrophila", FISH SHELLF, 11(2), 2001, pp. 101-113

Abstract

The serum of blue gourami, Trichogaster trichopterus (Pallus), contains a calcium-dependent, N-acetyl-galactosamine-binding lectin (BGL) which efficiently activates and enhances the non-specific immune response of fish towards a virulent strain of Aeromonas hydrophila. In the in vitro studies, a lectin concentration range of 0.05-1.0 ng ml(-1) was found to significantly promote phagocytic uptake of the bacteria by macrophages: This effect was further augmented when purified lectin was combined with laminarin (beta -1,3-D-glucan). Supernatants obtained from these lectin-stimulated macrophage cultures also exhibited significant bacteria-killing activities. In addition, complement from naive fish serum, in the presence of purified BCTL, was able to kill A. hydrophila. Finally, challenge experiments demonstrated thatBGL could confer effective immune protection to naive blue gourami againstan Aeromonas infection. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/10/17 alle ore 11:07:19