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Titolo:
Novel single nucleotide polymorphisms of the human nuclear factor kappa-B 2 gene identified by sequencing the entire gene
Autore:
Shinohara, Y; Iwasaki, H; Ota, N; Nakajima, T; Kodaira, M; Kajita, M; Shiba, T; Emi, M;
Indirizzi:
Nippon Med Sch, Inst Gerontol, Dept Mol Biol, Nakahara Ku, Kawasaki, Kanagawa 2118533, Japan Nippon Med Sch Kawasaki Kanagawa Japan 2118533 i, Kanagawa 2118533, Japan Kitasato Univ, Dept Mol Biol, Sagamihara, Kanagawa 228, Japan Kitasato Univ Sagamihara Kanagawa Japan 228 gamihara, Kanagawa 228, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 1, volume: 46, anno: 2001,
pagine: 50 - 51
SICI:
1434-5161(2001)46:1<50:NSNPOT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA REPEAT SEQUENCE; LOCUS;
Keywords:
nuclear factor kappa-B; single nucleotide polymorphism; Japanese population; inflammation; bone differentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
3
Recensione:
Indirizzi per estratti:
Indirizzo: Emi, M Nippon Med Sch, Inst Gerontol, Dept Mol Biol, Nakahara Ku, 1-396 Kosugi Cho, Kawasaki, Kanagawa 2118533, Japan Nippon Med Sch 1-396 Kosugi ChoKawasaki Kanagawa Japan 2118533 pan
Citazione:
Y. Shinohara et al., "Novel single nucleotide polymorphisms of the human nuclear factor kappa-B 2 gene identified by sequencing the entire gene", J HUM GENET, 46(1), 2001, pp. 50-51

Abstract

The nuclear factor kappa-B 2 (NFKB2) gene is a member of the NFKB/Rel genefamily, which is known to be a pivotal regulator of the acute phase of theinflammatory response and of immune responses. We identified three novel single nucleotide polymorphisms (SNPs) and determined their allelic frequencies, as determined by the sequencing of 48 alleles of the entire: gene in aJapanese population sample. Two Of the three polymorphisms were identifiedat nucleotide (nt) position 1837 (T/C) and nt position. 1867 (GG/G) in theupstream region of the gene. The other polymorphism was identified at nt position 2584 (G/T) within intron 1. These polymorphisms will be useful in genetic studies of the processes involved in inflammatory responses and in bone differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/06/18 alle ore 00:52:38