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Titolo:
Five novel single-nucleotide polymorphisms of human interferon gamma identified by sequencing the entire gene
Autore:
Iwasaki, H; Ota, N; Nakajima, T; Shinohara, Y; Kodaira, M; Kajita, M; Emi, M;
Indirizzi:
Nippon Med Sch, Inst Gerontol, Dept Mol Biol, Nakahara Ku, Kawasaki, Kanagawa 2118533, Japan Nippon Med Sch Kawasaki Kanagawa Japan 2118533 i, Kanagawa 2118533, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 1, volume: 46, anno: 2001,
pagine: 32 - 34
SICI:
1434-5161(2001)46:1<32:FNSPOH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA REPEAT SEQUENCE; DINUCLEOTIDE REPEAT; PROMOTER; LOCUS; MODULATION;
Keywords:
interferon gamma; singie-nucleotide polymorphism; Japanese population; inflammation; calcium metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Emi, M Nippon Med Sch, Inst Gerontol, Dept Mol Biol, Nakahara Ku, 1-396 Kosugi Cho, Kawasaki, Kanagawa 2118533, Japan Nippon Med Sch 1-396 Kosugi ChoKawasaki Kanagawa Japan 2118533 pan
Citazione:
H. Iwasaki et al., "Five novel single-nucleotide polymorphisms of human interferon gamma identified by sequencing the entire gene", J HUM GENET, 46(1), 2001, pp. 32-34

Abstract

Interferon gamma (IFNG) plays important roles in the regulation of bone remodelling. We describe here six single-nucleotide polymorphisms (SNPs) in the IFNG gene, five of which are novel, and their allelic frequencies in theJapanese population, as determined by sequencing 48 alleles of the entire gene. Four of these polymorphisms were identified inside the third intron, at nucleotide (nt) positions 2459 (A/G), 2671 (T/C), 3177 (T/G), and 3273 (G/A). In exon 4, SNPs were identified at nt positions 5199 (A/T) and 5272 (A/G). These polymorphic sites will be useful for genetic studies of disorders that affect the inflammatory process or calcium metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/06/18 alle ore 17:06:37