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Titolo:
Association between Novelty Seeking and the-521 C/T polymorphism in the promoter region of the DRD4 gene
Autore:
Ronai, Z; Szekely, A; Nemoda, Z; Lakatos, K; Gervai, J; Staub, M; Sasvari-Szekely, M;
Indirizzi:
Semmelweis Univ Med, Inst Med Chem Mol Biol & Pathobiochem, H-1444 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1444 em, H-1444 Budapest, Hungary Lorand Eotvos Univ, Inst Psychol, H-1378 Budapest, Hungary Lorand Eotvos Univ Budapest Hungary H-1378 hol, H-1378 Budapest, Hungary Hungarian Acad Sci, Inst Psychol, Social Dev Grp, H-1394 Budapest, HungaryHungarian Acad Sci Budapest Hungary H-1394 Grp, H-1394 Budapest, Hungary
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 1, volume: 6, anno: 2001,
pagine: 35 - 38
SICI:
1359-4184(200101)6:1<35:ABNSAT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PERSONALITY-TRAIT; D4 RECEPTOR GENE; DOPAMINE-D4 RECEPTOR; REPEAT POLYMORPHISM; EXON; SCHIZOPHRENIA; POPULATION; BEHAVIORS; VARIANT; D-2;
Keywords:
human personality; Novelty Seeking; DRD4 promoter; single nucleotide polymorphism (SNP); dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Sasvari-Szekely, M Semmelweis Univ Med, Inst Med Chem Mol Biol & Pathobiochem, POB 260, H-1444 Budapest, Hungary Semmelweis Univ Med POB 260 Budapest Hungary H-1444 ry
Citazione:
Z. Ronai et al., "Association between Novelty Seeking and the-521 C/T polymorphism in the promoter region of the DRD4 gene", MOL PSYCHI, 6(1), 2001, pp. 35-38

Abstract

Association between the human personality trait 'Novelty Seeking' and the polymorphism of the DRD4 gene was first reported by Ebstein(1) and Benjamin(2) in 1996. This was soon followed by replication studies in various ethnic groups and by studying the role of other neurotransmitter receptor and transporter genes in the genetic determination of human temperament. More recently, several polymorphic sites of the upstream regulatory region of the DRD4 gene have been described.(3) Among these the -521 C/T single nucleotidepolymorphism (SNP) was shown to be associated with the Novelty Seeking (NS) scores of the Temperament and Character Inventory (TCI) in a Japanese male population.(4) We have investigated the -521 C/T SNP polymorphism in a Caucasian (Hungarian) population,(5) and here we report a replication of the Japanese findings, in an association study involving 109 healthy Hungarian volunteers. We found a weak association between NS and CC vs CT or TT genotypes (P < 0.06). Examination of this relation in male and female sex groups, however, strengthened the association for females (P < 0.01), but showed no genotypic effect for males.

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Documento generato il 22/04/18 alle ore 20:26:42