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Titolo:
QT-prolonging effects of sparfloxacin, a fluoroquinolone antibiotic, assessed in the in vivo canine model with monophasic action potential monitoring
Autore:
Satoh, Y; Sugiyama, A; Chiba, K; Tamura, T; Hashimoto, K;
Indirizzi:
Yamanashi Med Univ, Dept Pharmacol, Yamanashi 4093898, Japan Yamanashi MedUniv Yamanashi Japan 4093898 col, Yamanashi 4093898, Japan Koshu Rehabil Hosp, Dept Med, Koshu, Japan Koshu Rehabil Hosp Koshu Japan shu Rehabil Hosp, Dept Med, Koshu, Japan Yamanashi Med Univ, Dept Internal Med 2, Yamanashi, Japan Yamanashi Med Univ Yamanashi Japan ept Internal Med 2, Yamanashi, Japan
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
fascicolo: 4, volume: 36, anno: 2000,
pagine: 510 - 515
SICI:
0160-2446(200010)36:4<510:QEOSAF>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPOLARIZATION; REFRACTORINESS; ASTEMIZOLE;
Keywords:
sparfloxacin; monophasic action potential; long-QT syndrome; 1(Kr) blocker; postrepolarization refractoriness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Sugiyama, A Yamanashi Med Univ, Dept Pharmacol, Yamanashi 4093898, Japan Yamanashi Med Univ Yamanashi Japan 4093898 hi 4093898, Japan
Citazione:
Y. Satoh et al., "QT-prolonging effects of sparfloxacin, a fluoroquinolone antibiotic, assessed in the in vivo canine model with monophasic action potential monitoring", J CARDIO PH, 36(4), 2000, pp. 510-515

Abstract

Sparfloxacin, a fluoroquinolone antibacterial agent, prolongs cardiac repolarization, which may predispose to torsades de pointes. This study was designed to assess simultaneously the hemodynamic and electrophysiologic effects of sparfloxacin using the halothane-anesthetized, closed-chest in vivo canine model (n = 6). Sparfloxacin was intravenously administered in the following two doses with a pause of 20 min, a clinically relevant dose of 3.0 mg/kg/10 min and a 10 times higher dose of 30 mg/kg/10 min. After the low dose of sparfloxacin, cardiac output increased, heart rate decreased, and ventricular repolarization and refractory periods were prolonged. After the high dose, cardiac output increased, whereas heart rate and mean blood pressure decreased, and ventricular repolarization and effective refractory periods were prolonged. The increment was greater in repolarization than in refractoriness, indicating an increase of electrical vulnerability. Because sparfloxacin prolonged repolarization in a reverse use-dependent manner, its negative chronotropic effect may have potentiated the QT prolongation. Leftventricle preload, left ventricular contraction, and AV nodal as well as intraventricular conduction were minimally affected. These results suggest that caution should be used when administering sparfloxacin to patients having risk factors for QT prolongation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/06/18 alle ore 17:18:00