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Titolo:
Effects of a class III antiarrhythmic drug, dofetilide, on the in situ canine heart assessed by the simultaneous monitoring of hemodynamic and electrophysiological parameters
Autore:
Satoh, Y; Sugiyama, A; Tamura, K; Hashimoto, K;
Indirizzi:
Yamanashi Med Univ, Dept Pharmacol, Tamaho, Yamanashi 4093898, Japan Yamanashi Med Univ Tamaho Yamanashi Japan 4093898 amanashi 4093898, Japan Yamanashi Med Univ, Dept Internal Med 2, Tamaho, Yamanashi 4093898, Japan Yamanashi Med Univ Tamaho Yamanashi Japan 4093898 amanashi 4093898, Japan
Titolo Testata:
JAPANESE JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 81, anno: 1999,
pagine: 79 - 85
SICI:
0021-5198(199909)81:1<79:EOACIA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTREPOLARIZATION REFRACTORINESS; ANESTHETIZED DOGS; POSITIVE INOTROPY; GUINEA-PIG; UK-68,798; POTENT; AGENT; REPOLARIZATION; MYOCARDIUM; ASTEMIZOLE;
Keywords:
dofetilide; monophasic action potential; long QT syndrome; I-Kr blocker; post repolarization refractoriness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Sugiyama, A Yamanashi Med Univ, Dept Pharmacol, Tamaho, Yamanashi 4093898,Japan Yamanashi Med Univ Tamaho Yamanashi Japan 4093898 3898, Japan
Citazione:
Y. Satoh et al., "Effects of a class III antiarrhythmic drug, dofetilide, on the in situ canine heart assessed by the simultaneous monitoring of hemodynamic and electrophysiological parameters", JPN J PHARM, 81(1), 1999, pp. 79-85

Abstract

The cardiovascular pro file of dofetilide was examined using halothane-anesthetized, closed-chest in vivo canine model (n = 6). Dofetilide was administered at the dose of 1, 10 or 100 mu g/kg, i.v. over 10 min with a pause of 20 min. After the lowest infusion rate, no significant change was detected in any of the cardiovascular parameters. Infusion of 10 mu g/kg dofetilide, which was close to the submaximal clinically effective antiarrhythmic dose, decreased the heart rate and prolonged the ventricular repolarization phase and refractory period. After the highest dose of dofetilide, the cardiac output and left ventricular contraction decreased during sinus rhythm, the latter of which was not changed during the constant heart rate of 150 beats/min, while the dose-related effects were observed on the heart rate, repolarization phase and refractory period. The afterload and preload to the left ventricle and AV nodal as well as intraventricular conductions were hardly affected even at 100 mu g/kg, i.v. These results obtained in the in vivo canine model support the previous reports describing that dofetilide possesses a highly selective blocking property for I-Kr. Moreover, the absenceof effects on the afterload and preload to the left ventricle and the cardiac conduction makes dofetilide favorable as an antiarrhythmic drug becauseit is often used for patients with moderate to severe left ventricular dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/06/18 alle ore 16:58:03