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Titolo:
A double-blind, single-dose, crossover comparison of cetirizine, ebastine,epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in
Autore:
Grant, JA; Danielson, L; Rihoux, JP; DeVos, C;
Indirizzi:
Univ Texas, Med Branch, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 as, Med Branch, Galveston, TX 77555 USA UCB Pharma, Braine Alleud, Belgium UCB Pharma Braine Alleud BelgiumUCB Pharma, Braine Alleud, Belgium
Titolo Testata:
ALLERGY
fascicolo: 7, volume: 54, anno: 1999,
pagine: 700 - 707
SICI:
0105-4538(199907)54:7<700:ADSCCO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLERGIC RHINITIS; RECEPTOR; PHARMACOLOGY; PHARMACODYNAMICS; PHARMACOKINETICS; ANTIHISTAMINE; ANTAGONIST; ASTEMIZOLE; CHILDREN; ASTHMA;
Keywords:
cetirizine; ebastine; epinastine; fexofenadine; histamine; histamine H-1-antagonists; loratadine; skin tests; terfenadine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Grant, JA Univ Texas, Med Branch, 301 Univ Blvd, Galveston, TX 77555 USA Univ Texas 301 Univ Blvd Galveston TX USA 77555 on, TX 77555 USA
Citazione:
J.A. Grant et al., "A double-blind, single-dose, crossover comparison of cetirizine, ebastine,epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in", ALLERGY, 54(7), 1999, pp. 700-707

Abstract

Background: New H-1-antagonists have become available, but there has been no comparison of their potency for inhibiting histamine in the skin. Methods: Cetirizine 10 mg, ebastine 10 mg, epinastine 20 mg, fexofenadine 60 mg, terfenadine 60 mg, loratadine 10 mg, or placebo was given to 14 healthy male volunteers in a double-blind, crossover randomized manner. Inhibition of the wheal and flare response to epicutaneous histamine phosphate (100 mg/ml) challenge was measured at 0, 0.5, 1, 2, 4, 6, 8, In, 12, and 24 h after doses. Results: Epinastine inhibited the wheal and flare after 30 min. Cetirizinecommenced acting at 1 h and was superior to other treatments. Ebastine wasno better than placebo until 4 h, but was efficacious thereafter until 24 h. Terfenadine induced potent inhibition after 1 h and was superior to its metabolite fexofenadine. Loratadine was the least potent inhibitor. Inhibition of the flare response paralleled the patterns seen for wheals. The rankorder for area under the curve (0-24 h) was cetirizine, epinastine, terfenadine, ebastine, fexofenadine, loratadine, and placebo. Conclusions: The inhibition of histamine effects in the skin may be usefulin predicting the clinical utility of newly introduced antihistamines in treating allergic disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/06/18 alle ore 17:00:14