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Titolo:
Decrease in red blood cell deformability caused by hypothermia, hemodilution, and mechanical stress: Factors related to cardiopulmonary bypass
Autore:
Kameneva, MV; Undar, A; Antaki, JF; Watach, MJ; Calhoon, JH; Borovetz, HS;
Indirizzi:
Univ Pittsburgh, McGowan Ctr Artificial Organ Dev, Pittsburgh, PA 15219 USA Univ Pittsburgh Pittsburgh PA USA 15219 gan Dev, Pittsburgh, PA 15219 USA Baylor Coll Med, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ylor Coll Med, Houston, TX 77030 USA Univ Texas, Hlth Sci Ctr, San Antonio, TX USA Univ Texas San Antonio TX USA v Texas, Hlth Sci Ctr, San Antonio, TX USA
Titolo Testata:
ASAIO JOURNAL
fascicolo: 4, volume: 45, anno: 1999,
pagine: 307 - 310
SICI:
1058-2916(199907/08)45:4<307:DIRBCD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPEN-HEART SURGERY; CIRCULATORY ARREST; ARTIFICIAL-HEART; FLOW; METABOLISM; VISCOSITY; PERFUSION; HEMATOCRIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kameneva, MV Univ Pittsburgh, McGowan Ctr Artificial Organ Dev, 300 Technol Dr, Pittsburgh, PA 15219 USA Univ Pittsburgh 300 Technol Dr Pittsburgh PAUSA 15219 19 USA
Citazione:
M.V. Kameneva et al., "Decrease in red blood cell deformability caused by hypothermia, hemodilution, and mechanical stress: Factors related to cardiopulmonary bypass", ASAIO J, 45(4), 1999, pp. 307-310

Abstract

During extracorporeal circulation in cardiopulmonary bypass (CPB) surgery,blood is exposed to anomalous mechanical and environmental factors, such as high shear stress, turbulence, decreased oncotic pressure caused by dilution of plasma, and moderate and especially deep hypothermia widely applied during CPB in infants. These factors cause damage to the red blood cells (RBCs), which is manifest by immediate and delayed hemolysis and by changes in the mechanical properties of RBCs. These changes include, in particular, decrease in RBC deformability impeding the passage of RBCs through the microvessels and may contribute to the complications associated with CPB surgery. We investigated in vitro the independent and combined effects of hypothermia, plasma dilution, and mechanical stress on deformability of bovine RBCs. Our studies showed each of these factors to cause a significant decreasein the deformability of RBCs, especially acting synergistically. The impairment of RBC deformability caused by hypothermia was found to be more pronounced for RBCs suspended in phosphate buffered saline (PBS) than for RBCs suspended in plasma. The decrease in RBC deformability caused by mechanical stress was significantly exacerbated by dilution of plasma with PBS. In summary, results of our in vitro study strongly point to a possible detrimental consequence of conventional CPB arising from increased RBC rigidity, which may lead to impaired microcirculation and tissue oxygen supply.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/05/18 alle ore 13:01:28