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Titolo:
EFFICACY AND SAFETY RELATIVE TO PLACEBO OF AN ORAL FORMULATION OF CETIRIZINE AND SUSTAINED-RELEASE PSEUDOEPHEDRINE IN THE MANAGEMENT OF NASAL CONGESTION
Autore:
HORAK F; TOTH J; MARKS B; STUBNER UP; BERGER UE; JAGER S; BURTIN B; DUBY C;
Indirizzi:
UNIV VIENNA,AKH VIENNA,ENT CLIN,WAHRINGER GURTEL 18-20 A-1090 VIENNA AUSTRIA UCB BIOPROD SA,PHARMA SECTOR B-1420 BRAINE LALLEUD BELGIUM
Titolo Testata:
Allergy
fascicolo: 9, volume: 53, anno: 1998,
pagine: 849 - 856
SICI:
0105-4538(1998)53:9<849:EASRTP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERENNIAL ALLERGIC RHINITIS; VIENNA CHALLENGE CHAMBER; TOLERABILITY; TERFENADINE; ASTEMIZOLE; LORATADINE; ASTHMA;
Keywords:
CETIRIZINE; DIGITAL IMAGING; NASAL CONGESTION; PSEUDOEPHEDRINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
F. Horak et al., "EFFICACY AND SAFETY RELATIVE TO PLACEBO OF AN ORAL FORMULATION OF CETIRIZINE AND SUSTAINED-RELEASE PSEUDOEPHEDRINE IN THE MANAGEMENT OF NASAL CONGESTION", Allergy, 53(9), 1998, pp. 849-856

Abstract

Background The aim of this study was to assess the clinical efficacy of an oral formulation of cetirizine 5 mg with sustained-release pseudoephedrine (PSE) 120 mg relative to placebo in patients with nasal congestion. Methods Twenty-four patients with perennial rhinitis due to house-dust-mite (HDM) allergy were recruited in this crossover study. Atreatment period of 1 week, in which cetirizine/PSE was administered twice daily, was followed by a washout period of at least 2 weeks and a further period of 1 week in which the alternative treatment was given to each patient. Immediately after the first dose of each medication(day 1), nasal congestion and related symptoms were assessed during a7-h challenge with HDM feces, with the Vienna Challenge Chamber (VCC), to investigate onset of action of the preparation. A second challenge of 3-h duration, carried out at least 12 h after the final dose, wasundertaken after 1 week (mean) of twice-daily treatment to assess residual effects of the formulation after achievement of steady state. Results The oral formulation of cetirizine/PSE was significantly (P<0.001) superior to placebo in improving nasal obstruction during both challenges. The improvement in nasal airflow and nasal patency was significantly greater with cetirizine/PSE than with placebo (P<0.02). In addition, subjective assessment of nasal symptoms showed that cetirizine/PSE was significantly superior to placebo in both challenges for the sum of nasal obstruction scores Both medications were well tolerated, and no serious adverse events occurred during the study.Conclusions In this study, cetirizine/PSE relieved nasal congestion and other objective and subjective symptoms to a significantly greater extent than placebo. No serious adverse events occurred, and both regimens were equallywell tolerated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/06/18 alle ore 17:30:07