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Titolo:
ALTERNATIVE SPLICING OF ERCC1 AND CISPLATIN-DNA ADDUCT REPAIR IN HUMAN TUMOR-CELL LINES
Autore:
YU JJ; MU CJ; DABHOLKAR M; GUO Y; BOSTICKBRUTON F; REED E;
Indirizzi:
NCI,MED OVARIAN CANC SECT,DEV THERAPEUT DEPT,MED BRANCH,10-12N226 BETHESDA MD 20892 NCI,MED OVARIAN CANC SECT,DEV THERAPEUT DEPT,MED BRANCH BETHESDA MD 20892
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 3, volume: 1, anno: 1998,
pagine: 617 - 620
SICI:
1107-3756(1998)1:3<617:ASOEAC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCISION-REPAIR; MESSENGER-RNA; GENE ERCC-1; EXPRESSION; RESISTANCE; SENSITIVITY; DEFICIENCY; YEAST;
Keywords:
ALTERNATIVE SPLICING; ERCC1; DNA ADDUCT REPAIR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Yu et al., "ALTERNATIVE SPLICING OF ERCC1 AND CISPLATIN-DNA ADDUCT REPAIR IN HUMAN TUMOR-CELL LINES", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 1(3), 1998, pp. 617-620

Abstract

Alternative splicing is a common natural tool for the inhibition of function of full length gene products. We explored whether there was evidence that alternative splicing of ERCC1 may serve such a function for nucleotide excision repair. The ratio of alternatively spliced species to full length species was assessed for the protein and/or for the mRNA, for a series of human cell lines and tissues. This ratio was plotted against the amount of cisplatin-DNA adduct repair in each cell line (n = 9), as measured by atomic absorbance spectrometry. As the percentage of alternatively spliced protein and/or mRNA increased, the amount of cisplatin-DNA adduct that was repaired was reduced. This inverse relationship was associated with a substantial amount of scatter (r = 0.635), particularly at low levels of repair. These data demonstratean association between alternative splicing of ERCC1, and reduction in cellular capability to repair cisplatin-DNA adduct.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/06/18 alle ore 17:14:44