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Titolo:
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF O-METHYL DERIVATIVES OF AZALIDE ANTIBIOTICS - II - 6-OME DERIVATIVES VLA CLARITHROMYCIN
Autore:
WADDELL ST; SANTORELLI GM; BLIZZARD TA; GRAHAM A; OCCI J;
Indirizzi:
MERCK RES LABS,DEPT MED CHEM,POB 2000 RAHWAY NJ 07065 MERCK RES LABS,DEPT ENZYMOL RAHWAY NJ 07065
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 11, volume: 8, anno: 1998,
pagine: 1321 - 1326
SICI:
0960-894X(1998)8:11<1321:SAAAOO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMICAL MODIFICATION; ERYTHROMYCIN-A; BECKMANN REARRANGEMENT; 6-O-METHYLERYTHROMYCINS-A; INVITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
S.T. Waddell et al., "SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF O-METHYL DERIVATIVES OF AZALIDE ANTIBIOTICS - II - 6-OME DERIVATIVES VLA CLARITHROMYCIN", Bioorganic & medicinal chemistry letters, 8(11), 1998, pp. 1321-1326

Abstract

Direct O-methylation of various derivatives of 9-deoxo-8a- and 9a-aza-8a-homo-erythromycin (2',3'-bis-Cbz protected) gives 6-OMe derivatives only in a small number of special cases. The 6-OMe-azalides can, however, be synthesized beginning from clarithromycin. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/11/17 alle ore 05:51:31