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Titolo:
Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs
Autore:
de Abajo, FJ; Rodriguez, LAG;
Indirizzi:
Ctr Espanol Invest Farmacoepidemiol, Madrid 28004, Spain Ctr Espanol Invest Farmacoepidemiol Madrid Spain 28004 drid 28004, Spain Ctr Nacl Farmacobiol, Area Farmacovigilancia, Madrid, Spain Ctr Nacl Farmacobiol Madrid Spain Area Farmacovigilancia, Madrid, Spain
Titolo Testata:
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 3, volume: 47, anno: 1999,
pagine: 307 - 313
SICI:
0306-5251(199903)47:3<307:ROVAAW>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADE-DE-POINTES; ASTEMIZOLE OVERDOSE; TERFENADINE USE; LORATADINE;
Keywords:
ventricular arrhythmias; antihistamines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Rodriguez, LAG Ctr Espanol Invest Farmacoepidemiol, Almirante 28,2, Madrid28004, Spain Ctr Espanol Invest Farmacoepidemiol Almirante 28,2 Madrid Spain 28004
Citazione:
F.J. de Abajo e L.A.G. Rodriguez, "Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs", BR J CL PH, 47(3), 1999, pp. 307-313

Abstract

Aims To quantify and compare the incidence of ventricular arrhythmias associated with the use of five nonsedating antihistamines: acrivastine, astemizole, cetirizine, loratadine and terfenadine. The effects of age, sex, dose, duration of treatment, and the interaction with P450 inhibitor drugs werealso examined. Methods We carried out a cohort study with a nested case-control analysis using the UK-based General Practice Research Database (GPRD). The study cohort included persons aged less than 80 years old who received their first prescription for any of the five study drugs between January 1, 1992 and September 30, 1996. We estimated relative risks and 95% confidence intervals of idiopathic ventricular arrhythmias with current use of antihistamines as compared with non use. Results The study cohort included 197425 persons who received 513012 prescriptions. Over the study period 18 valid cases of idiopathic ventricular arrhythmias were detected. Nine occurred during the current use of any antihistamine, resulting in a crude incidence of 1.9 per 10000 person-years (95%CI: 1.0-3.6) and a relative risk of 4.2 (95%CI: 1.5-11.8) as compared with non use. Astemizole presented the highest relative risk (RR = 19.0; 95%CI: 4.8-76.0) of all study drugs, while terfenadine (RR=2.1; 95%CI:0.5-8.5) was in the range of other nonsedating antihistamines. Older age was associated with a greater risk of ventricular arrhythmias (RR=7.4; 95%CI: 2.6-21.4) and seemed to increase the effect of antihistamines (RR = 6.4; 95%CI: 1.7-24.8). The proportions of high dose terfenadine and the concomitant use with P450 inhibitors among current users of terfenadine were 2.7% and 3.4%, respectively over the study period with no single case of ventricular arrhythmias occurring in the presence of these two risk factors. Conclusions The use of nonsedating antihistamines increases the risk of ventricular arrhythmias by a factor of four in the general population. Yet, the absolute effect is quite low requiring 57000 prescriptions, or 5300 person-years of use for one case to occur. The risk associated with terfenadinewas no different from that with other nonsedating antihistamines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/06/18 alle ore 00:47:52