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Titolo: THE SPECIFIC EFFECTS OF PRIOR OPIOID EXPOSURE ON PLACEBO ANALGESIA AND PLACEBO RESPIRATORY DEPRESSION
Autore: BENEDETTI F; AMANZIO M; BALDI S; CASADIO C; CAVALLO A; MANCUSO M; RUFFINI E; OLIARO A; MAGGI G;
- Indirizzi:
- UNIV TURIN,SCH MED,DEPT NEUROSCI,CORSO RAFFAELLO 30 I-10125 TURIN ITALY UNIV TURIN,SCH MED,DEPT RESP PATHOPHYSIOL TURIN ITALY UNIV TURIN,SCH MED,DEPT THORAC SURG TURIN ITALY UNIV TURIN,SCH MED,CIND CTR NEUROPHYSIOL PAIN TURIN ITALY
- Titolo Testata:
- Pain
fascicolo: 2-3,
volume: 75,
anno: 1998,
pagine: 313 - 319
- SICI:
- 0304-3959(1998)75:2-3<313:TSEOPO>2.0.ZU;2-F
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- OPIATE ANTAGONIST; MECHANISMS; NALOXONE; BINDING; PROGLUMIDE; PAIN;
- Keywords:
- OPIOID; PLACEBO ANALGESIA; PLACEBO RESPIRATORY DEPRESSION; PAIN PERCEPTION;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Science Citation Index Expanded
- Science Citation Index Expanded
- Citazioni:
- 45
- Recensione:
- Indirizzi per estratti:
-
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- Citazione:
- F. Benedetti et al., "THE SPECIFIC EFFECTS OF PRIOR OPIOID EXPOSURE ON PLACEBO ANALGESIA AND PLACEBO RESPIRATORY DEPRESSION", Pain, 75(2-3), 1998, pp. 313-319
Abstract
Although in most of the cases the placebo response appears to be unpredictable, several factors have been considered in order to explain the placebo analgesic effect. For example, it is widely recognized, albeit with little empirical evidence, that placebo analgesia is more likely to occur after a successful analgesic therapy. On the basis of thisassumption, we tested the placebo response in a population of patients who were treated with buprenorphine the day before for relieving postoperative pain. However, due to the high variability of opioid responsiveness, buprenorphine was effective in some patients and poorly effective in some others. Similarly, buprenorphine produced respiratory depression with a large variability, ranging from mild depression to no effect. We found that the placebo analgesic response depended on the buprenorphine analgesic effectiveness of the previous day. Analogously,we found that a placebo respiratory depressant response was more pronounced in those patients with a respiratory depressant response to buprenorphine on the day before, irrespective of the analgesic effectiveness. These specific effects suggest that (1) the placebo effect is experience-dependent; (2) the mechanisms underlying placebo analgesia andplacebo respiratory depression are independent from each other and, by considering the role of endogenous opioids in placebo analgesia, might involve different subpopulations of opioid receptors. (C) 1998 International Association for the Study of Pain. Published by Elsevier Science B.V.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/05/13 alle ore 02:27:24