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Titolo: THE HUMAN PHASE RESPONSE CURVE (PRC) TO MELATONIN IS ABOUT 12 HOURS OUT-OF-PHASE WITH THE PRC TO LIGHT
Autore: LEWY AJ; BAUER VK; AHMED S; THOMAS KH; CUTLER NL; SINGER CM; MOFFIT MT; SACK RL;
- Indirizzi:
- OREGON HLTH SCI UNIV,DEPT PSYCHIAT,SLEEP & MOOD DISORDERS LAB,L469 PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT OPHTHALMOL PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT PHYSIOL & PHARMACOL PORTLAND OR 97201
- Titolo Testata:
- Chronobiology international
fascicolo: 1,
volume: 15,
anno: 1998,
pagine: 71 - 83
- SICI:
- 0742-0528(1998)15:1<71:THPRC(>2.0.ZU;2-E
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- HUMAN CIRCADIAN-RHYTHMS; MASS-SPECTROMETRY; BRIGHT LIGHT; JET LAG; RAT; PLASMA; SECRETION; CORTISOL; SYSTEMS; CLOCK;
- Keywords:
- MELATONIN ADMINISTRATION; MELATONIN PHASE RESPONSE CURVE; LIGHT PHASE RESPONSE CURVE; CIRCADIAN PHASE DISORDERS; DIM LIGHT MELATONIN ONSET;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Science Citation Index Expanded
- Citazioni:
- 58
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- A.J. Lewy et al., "THE HUMAN PHASE RESPONSE CURVE (PRC) TO MELATONIN IS ABOUT 12 HOURS OUT-OF-PHASE WITH THE PRC TO LIGHT", Chronobiology international, 15(1), 1998, pp. 71-83
Abstract
Melatonin's timekeeping function is undoubtedly related to the fact that it is primarily produced during nighttime darkness; that is, melatonin and light occur at opposite times. The human phase response curve(PRC) to melatonin appears to be about 12h out of phase with the PRC to light. These striking complementarities, together with light's acute suppressant effect on melatonin production, suggest that a function for endogenous melatonin is to augment entrainment of the circadian pacemaker by the light-dark cycle. The melatonin PRC also indicates correct administration times for using exogenous melatonin to treat circadian phase disorders.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/06/13 alle ore 11:25:32