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Titolo: THROMBOXANE A(2) INDUCES CELL SIGNALING BUT REQUIRES PLATELET-DERIVEDGROWTH-FACTOR TO ACT AS A MITOGEN
Autore: GROSSER T; ZUCKER TP; WEBER AA; SCHULTE K; SACHINIDIS A; VETTER H; SCHROR K;
- Indirizzi:
- UNIV DUSSELDORF,INST PHARMAKOL,MOORENSTR 5 D-40225 DUSSELDORF GERMANY UNIV DUSSELDORF,INST PHARMAKOL D-40225 DUSSELDORF GERMANY UNIV DUSSELDORF,INST KLIN ANAESTHESIOL D-40225 DUSSELDORF GERMANY UNIV BONN,MED POLIKLIN D-5300 BONN GERMANY
- Titolo Testata:
- European journal of pharmacology
fascicolo: 2-3,
volume: 319,
anno: 1997,
pagine: 327 - 332
- SICI:
- 0014-2999(1997)319:2-3<327:TAICSB>2.0.ZU;2-1
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- VASCULAR SMOOTH-MUSCLE; ACTIVATED PROTEIN-KINASE; DNA-SYNTHESIS; PDGF-AA; RESTENOSIS; PROLIFERATION; PROSTACYCLIN; TRANSDUCTION; ANGIOPLASTY; MECHANISMS;
- Keywords:
- CORONARY ARTERY SMOOTH MUSCLE CELL; MITOGENESIS; THROMBOXANE A(2); PDGF (PLATELET-DERIVED GROWTH FACTOR);
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 24
- Recensione:
- Indirizzi per estratti:
-
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- Citazione:
- T. Grosser et al., "THROMBOXANE A(2) INDUCES CELL SIGNALING BUT REQUIRES PLATELET-DERIVEDGROWTH-FACTOR TO ACT AS A MITOGEN", European journal of pharmacology, 319(2-3), 1997, pp. 327-332
Abstract
This study investigates thromboxane A(2)-induced cell signaling and mitogenesis of bovine coronary artery smooth muscle cells. The thromboxane mimetic U 46619 )-hydroxy-11,9-(epoxymethano)prosta-5Z,13E-dienoicacid] (10 mu M) stimulated [Ca2+](i) signals, phosphorylation of MAP kinase (mitogen-activated protein kinase). and expression of c-fos mRNA in smooth muscle cells. In contrast, no stimulation of DNA synthesisor cell proliferation by U 46619 was observed. However, platelet-derived growth factor-BB (20 ng/ml)-induced mitogenesis was potentiated byU 46619. Similar results were obtained with I-BOP [1S-(1 alpha,2 beta(5Z),3 alpha(1E,3R),4 alpha)]7-[3-(3- hydroxy-4-(4'-iodophenoxy)- butenyl)-7-oxabicyc[2.2.1]heptan-2-yl]-5-heptenoic acid]. These potentiating effects were abrogated by a specific thromboxane receptor antagonist, suggesting that the potentiation of platelet-derived growth factor-BB-induced smooth muscle cell mitogenesis by U 46619 and I-BOP was mediated by thromboxane receptors. It is concluded that thromboxane A, generated by blood platelets at the site of vessel injury induces cell signaling in smooth muscle cells but acts as a mitogen only in the presence of growth factor(s).
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/05/13 alle ore 08:10:11