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Titolo:
CLINICAL STRAIN OF STAPHYLOCOCCUS-AUREUS INACTIVATES AND CAUSES EFFLUX OF MACROLIDES
Autore:
WONDRACK L; MASSA M; YANG BV; SUTCLIFFE J;
Indirizzi:
PFIZER INC,DIV CENT RES,DEPT INFECT DIS,EASTERN POINT RD GROTON CT 06340 PFIZER INC,DIV CENT RES,DEPT INFECT DIS GROTON CT 06340 PFIZER INC,DIV CENT RES,DEPT MED CHEM GROTON CT 06340
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 4, volume: 40, anno: 1996,
pagine: 992 - 998
SICI:
0066-4804(1996)40:4<992:CSOSIA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED ERYTHROMYCIN RESISTANCE; CONFER INDUCIBLE RESISTANCE; STREPTOGRAMIN-B RESISTANCE; RNA METHYLASE GENES; ESCHERICHIA-COLI; HIGHLY RESISTANT; RIBOSOMAL-RNA; BECKMANN REARRANGEMENT; BACTERIAL-RESISTANCE; NUCLEOTIDE-SEQUENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
L. Wondrack et al., "CLINICAL STRAIN OF STAPHYLOCOCCUS-AUREUS INACTIVATES AND CAUSES EFFLUX OF MACROLIDES", Antimicrobial agents and chemotherapy, 40(4), 1996, pp. 992-998

Abstract

Searching through a collection of 124 Staphylococcus aureus clinical strains, we found one isolate, strain 01A1032, that inactivates 14- and 16-membered macrolides, The products of inactivation were purified from supernatant fluids of cultures exposed to erythromycin for 30 h and were found to be identical to products of inactivation from Escherichia coli strains that encode either an EreA or EreB esterase, Further,strain 01A1032 was shown to be resistant to azithromycin, a 15-membered macrolide, by an alternate mechanism, efflux. Thus, strain 01A1032 harbors determinants encoding an esterase activity that hydrolyzes 14-and 16-membered macrolides and a macrolide efflux system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/11/17 alle ore 05:52:23