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Titolo:
5-HT1D RECEPTOR-TYPE IS INVOLVED IN STIMULATION OF CELL-PROLIFERATIONBY SEROTONIN IN HUMAN SMALL-CELL LUNG-CARCINOMA
Autore:
CATTANEO MG; PALAZZI E; BONDIOLOTTI G; VICENTINI LM;
Indirizzi:
UNIV MILAN,SCH MED,DEPT PHARMACOL,VIA VANVITELLI 32 I-20129 MILAN ITALY UNIV MILAN,SCH MED,DEPT PHARMACOL I-20129 MILAN ITALY
Titolo Testata:
European journal of pharmacology. Molecular pharmacology section
fascicolo: 3, volume: 268, anno: 1994,
pagine: 425 - 430
SICI:
0922-4106(1994)268:3<425:5RIIIS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-SYNTHESIS; GROWTH-FACTOR; CANCER; FIBROBLASTS; PATHWAY;
Keywords:
5-HT, (SEROTONIN); 5-HT RECEPTOR; SMALL CELL LUNG CARCINOMA CELL; PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M.G. Cattaneo et al., "5-HT1D RECEPTOR-TYPE IS INVOLVED IN STIMULATION OF CELL-PROLIFERATIONBY SEROTONIN IN HUMAN SMALL-CELL LUNG-CARCINOMA", European journal of pharmacology. Molecular pharmacology section, 268(3), 1994, pp. 425-430

Abstract

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter and vasoactive agent, is contained in two small cell lung carcinoma cell lines GLC8 and NCI-N-592 and is released in the culture medium. It also stimulates DNA synthesis in the same cell lines. In GLC8 cells this mitogenic effect is not counteracted by ketanserin, ICS 205-930 and GR 113-808which are antagonists of the 5-HT2, 5-HT3 and 5-HT4 receptors, respectively. On the contrary, the antagonists meter,ooline, methysergide, SDZ 21-009 and methiothepin inhibit the 5-HT-stimulated incorporation of [H-3]thymidine in GLC8 cells. The 5-HT1D agonist sumatriptan is capable of mimicking 5-HT action on cell proliferation. Both sumatriptan and 5-HT inhibit adenylate cyclase activity at doses which correlate with the mitogenic effect. We conclude that a 5-HT1D receptor type contributes to the mitogenic effect of 5-HT in GLC8 cells. This is the first demonstration of an involvement of the 5-HT1D receptor type in humancell proliferation. The design of specific antagonists for this type of receptor might be useful for the growth control of this very aggressive tumor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/17 alle ore 11:07:57